Retinoblastoma (ICD10 C69.2)

T1, T2, T3

N0

M0

T4a

N0

M0

T4b

N0

M0

Any T

N1

M0

Any T

Any N

M1

T1, T2, T3

N0

M0

T4

N0

M0

Any T

N1

M0

Any T

Any N

M1

cTX

Primary tumour cannot be assessed.

cT0

No evidence of primary tumour.

cT1

Tumour confined to the retina with subretinal fluid no more than 5 mm from the base of any tumour, without retinal detachment

cT1a - No tumour in either eye is greater than 3 mm in largest dimension or located closer than 1.5 mm to the optic nerve or fovea

cT1b - At least one tumour is greater than 3 mm in largest dimension or located closer than 1.5 mm to the optic nerve or fovea. No retinal detachment or subretinal fluid beyond 5 mm from the base of the tumour

cT2

Tumours with vitreous or subretinal seeding or retinal detachment

cT2a - Tumour with subretinal fluid more than 5 mm from the base of any tumour

cT2b - Tumour with vitreous and/or subretinal seeding

cT3

Severe intraocular disease

cT3a - Phthisis or prephthisis bulbi

cT3b - Invasion of  choroid, pars plana, ciliary body, lens, zonules, iris or anterior chamber

cT3c - Raised intraocular pressure with neovascularization and/or buphthalmos

cT3d - Hyphema and/or massive vitreous haemorrhage

cT3e - Aseptic orbital cellulitis

cT4

Extraocular tumour

cT4a - Invasion of optic nerve or orbital tissues

cT4b - Extraocular invasion with proptosis and/or orbital mass

cNX

Regional lymph nodes cannot be assessed

cN0

No regional lymph node metastasis

cN1

Regional lymph node metastasis

cM0

No distant metastasis

cM1

Distant Metastasis

cM1a- Single or multiple metastasis to sites other than CNS or brain

cM1b - Metastasis to the CNS including brain

pTX

Primary tumour cannot be assessed

pT0

No evidence of primary tumour

pT1

Tumour confined to eye with no optic nerve or choroidal invasion

pT2

Tumour with intraocular invasion

pT2a - Focal choroidal invasion and pre‐ or intralaminar invasion of the optic nerve head

pT2b - Tumour invasion of stroma of iris and/or trabecular meshwork and/or Schlemm canal

pT3

Tumour with significant local invasion

pT3a - Choroidal invasion larger than 3 mm in diameter or multiple foci of invasion totalling more than 3 mm or any full‐thickness involvement

pT3b - Retrolaminar invasion of optic nerve without invasion of transected end of optic nerve

pT3c - Partial‐thickness involvement of sclera within the inner two‐thirds

pT3d - Full‐thickness invasion into outer third of the sclera and/or invasion into or around emissary channels

pT4

Extraocular extension: Tumour invades optic nerve at transected end, in meningeal space around the optic nerve, full‐thickness invasion of the sclera with invasion of the episclera, adipose tissue, extraocular muscle, bone, conjunctiva, or eyelid.

pNX

Regional lymph nodes cannot be assessed

pN0

No regional lymph node involvement

pN1

Regional lymph node involvement

cM0

No distant metastasis

pM1

Distant Metastasis

pM1a - Single or multiple metastasis to sites other than CNS

pM1b - Metastasis to CNS parenchyma or cerebrospinal  fluid