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Part of Cancer staging guidance sheets

Intrahepatic bile ducts (ICD10 C22.1)

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Introduction

This is the data sheet for TNM 9th edition staging of the intrahepatic bile duct (ICD10 C22.1)

For more detailed information regarding TNM staging, please see pages 85-86 of the UICC TNM 9 book.

Stage groupings

Stage Group

T stage

N stage

M stage

Stage 0

Tis

N0

M0

Stage I

T1

N0

M0

Stage IA

T1a

N0

M0
Stage IB

T1b

N0

M0

Stage II

T2

N0

M0

Stage IIIA

T3

N0

M0

Stage IIIB

T4

N0

M0

Any T

N1

M0

Stage IV

Any T

Any N

M1

TNM clinical classification

T - primary tumour

T value

Description

cTX

Primary tumour cannot be assessed

cT0

No evidence of primary tumour

cTis

Carcinoma in situ (intraductal tumour)

cT1

Solitary tumour with vascular invasion

cT1a - Solitary tumour 5 cm or less in greatest dimension without vascular invasion

cT1b - Solitary tumour more than 5 cm in greatest dimension without vascular invasion

cT2

Solitary tumour with intrahepatic vascular invasion or multiple tumours, with or without vascular invasion

cT3

Tumour perforating the visceral peritoneum

cT4

Tumour involving local extrahepatic structures by direct hepatic invasion

N - regional lymph nodes

N value

Description

cNX

Regional lymph nodes cannot be assessed

cN0

No regional lymph node metastasis

cN1

Regional lymph node metastasis

M - distant metastasis

M value Description

cM0

No distant metastasis

cM1

Distant metastasis

TNM pathological classification

pT - primary tumour

The pT and pN categories correspond to the cT and cN categories as per above.

pN - regional lymph nodes

pN value Description

pN0

Histological examination of a regional lymphadenectomy specimen should ordinarily include 6 or more lymph nodes. If the regional lymph nodes are negative, but the number ordinarily examined is not met, classify as pN0

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Last edited: 16 January 2026 4:10 pm

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  1. Cancer staging guidance sheets
  2. Oral Cavity and mucosal lip (ICD10 C00.3-5, C02-C06)
  3. Malignant melanoma of upper aerodigestive tract (ICD10 C00-06, C09-14, C30-32)
  4. Pharynx (ICD10 C01, C02.4, C05.1-2, C09, C10.0, C10.2-3, C10.9, C11-13)
  5. Salivary glands (ICD10 C00-C14, C15.0, C30-C33, C41.1)
  6. Oesophagus including oesophagogastric junction (ICD10 C15, C16.0)
  7. Gastrointestinal stromal tumours (ICD10 C15-C20, C48.1-2)
  8. Stomach (ICD10 C16 - excluding C16.0)
  9. Small intestine (ICD10 C17)
  10. Appendix (ICD10 C18.1)
  11. Colon and rectum (ICD10 C18-C20)
  12. Anal and perianal skin (ICD10 C21)
  13. Liver (ICD10 C22.0)
  14. Intrahepatic bile ducts (ICD10 C22.1)
  15. Gallbladder (ICD10 C23)
  16. Distal extrahepatic bile duct (ICD10 C24.0)
  17. Perihilar bile ducts (ICD10 C24.0)
  18. Ampulla of vater (ICD10 C24.1)
  19. Pancreas (ICD10 C25)
  20. Nasal cavity and paranasal sinuses (ICD10 C30.0, C31.0, C31.1)
  21. Larynx (ICD10 C32.0, C32.1, C32.2, C10.1)
  22. Lung (ICD10 C34)
  23. Thymus tumours (ICD10 C37.9)
  24. Soft tissues (ICD10 C15-C26, C34-C37 C38.1-3, C47-C49, C51-C53, C58, C60-C68)
  25. Bone (ICD10 C40, C41)
  26. Melanoma of skin (ICD10 C00.0-2, C00.6, C21.2, C43, C51, C60, C63.2)
  27. Merkel cell carcinoma of skin (ICD10 C00, C44, C51, C60, 63.2, C80)
  28. Skin carcinoma of the head and neck (ICD10 C00.0-2, C00.6, C44.0, C44.2-4)
  29. Carcinoma of skin of the eyelid (ICD10 C44.1)
  30. Carcinoma of skin (excluding eyelid, head and neck, perianal, vulva and penis) (ICD10 C44.5-7, C63.2)
  31. Pleural mesothelioma (ICD10 C38.4)
  32. Breast tumours (ICD10 C50)
  33. Vulva (ICD10 C51)
  34. Cervix uteri (ICD10 C53)
  35. Uterine sarcomas
  36. Uterus - endometrium (ICD10 C54.1, C55)
  37. Ovarian, fallopian tube and primary peritoneal carcinoma (ICD10 C56, C57, C48.1, C48.2)
  38. Gestational trophoblastic neoplasms (ICD10 C58)
  39. Penis tumours (ICD10 C60)
  40. Prostate tumours (ICD10 C61.9)
  41. Testis tumours (ICD10 C62)
  42. Kidney tumours (ICD10 C64)
  43. Renal pelvis and ureter tumours (ICD10 C65 & C66)
  44. Urinary bladder tumours (ICD10 C67)
  45. Urethra tumours (ICD10 C68.0, C61.9)
  46. Carcinoma of conjuctiva (ICD10 C69.0)
  47. Melanoma of conjuctiva (ICD10 C69.0)
  48. Retinoblastoma (ICD10 C69.2)
  49. Melanoma of uvea (ICD10 C69.3-4)
  50. Carcinoma of lacrimal gland (ICD10 C69.5)
  51. Sarcoma of orbit (ICD10 C69.6)
  52. Thyroid gland (ICD10 C73.9)
  53. Adrenal cortex (ICD10 C74.0)
  54. Adrenal medulla and extra-adrenal paraganglia (ICD10 C74.1 C75.5)
  55. Parathyroid gland (ICD10 C75.0)
  56. Unknown primary - cervical nodes (ICD10 C77.0)
  57. Mycosis fungoides or sezary syndrome (ICD10 C84.0 and C84.1)
  58. T and B cutaneous lymphoma (ICD10, C82.6, C84.8, C86.6 and other C83-C86 if primary skin excluding C84.0 C84.1)
  59. Rhabdomyosarcoma (CTYA)
  60. Chronic lymphocytic leukaemia
  61. Hepatoblastoma (CTYA)
  62. Hodgkins and non-hodgkins lymphoma (ICD10 C81-88)
  63. Medulloblastoma
  64. Multiple myeloma
  65. Neuroblastoma
  66. Neuroendocrine tumours of the foregut
  67. Neuroendocrine tumours of the midgut and hindgut
  68. Non-hodgkin lymphoma (children)
  69. Wilms tumour of the kidney